Brain Health Supplement — NAD+, Alpha-GPC, B12 & Folate

NAD+ (nicotinamide adenine dinucleotide)

NAD+ is a naturally occurring coenzyme involved in cellular energy metabolism and redox biology. In metabolic redox reactions, NAD+ and NADH cycle between oxidized and reduced forms, helping cells move electrons through energy-producing pathways. [1]

In Fmlave Brain Health, NAD+ is used as direct NAD+ — not NR, NMN, or another NAD+ precursor. It provides the cellular energy metabolism layer of the formula and works alongside Alpha-GPC for choline-pathway support, plus vitamin B12 and folate for nervous-system and methylation support. [2]

Evidence note: The Supplement Facts panel lists NAD+ at 100 mg per capsule. A third-party batch report identifies NAD+ / β-Diphosphopyridine nucleotide in the tested Brain Health sample at 338 mg/g.

References:
[1] Farhana A, Lappin SL. Biochemistry, Electron Transport Chain. StatPearls. Treasure Island (FL): StatPearls Publishing; updated 2023.
[2] Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology. 2021;22:119–141.

Alpha-GPC (GPC as L-alpha-Glycerylphosphorylcholine)

Alpha-GPC is a common name for L-alpha-Glycerylphosphorylcholine, also known as choline alfoscerate. It is a choline-containing compound and is listed on this product’s Supplement Facts panel as GPC, as L-alpha-Glycerylphosphorylcholine. [1]

In Fmlave Brain Health, Alpha-GPC is included as a choline-source ingredient. Choline is needed by the body to produce acetylcholine, a neurotransmitter involved in memory, mood, muscle control, and other brain and nervous-system functions. [2]

Alpha-GPC is not positioned here as a stimulant or drug-like enhancer. Its role in this formula is choline-pathway support, paired with direct NAD+ for cellular energy metabolism and B vitamins for nervous-system and methylation support. [3]

Also known as: GPC, Alpha-GPC, L-alpha-Glycerylphosphorylcholine, L-α-GPC, choline alfoscerate.

References:
[1] PubChem. Choline Alfoscerate, CID 657272.
[2] National Institutes of Health, Office of Dietary Supplements. Choline — Consumer Fact Sheet. Updated June 2, 2022.
[3] Liu Y, et al. Unlocking the Potential of l-α-Glycerylphosphorylcholine: From Metabolic Pathways to Therapeutic Applications. Nutrition Reviews. 2025;83(8):1594.

Folate

Folate is a water-soluble B vitamin involved in one-carbon metabolism, amino acid metabolism, and the synthesis of nucleic acids such as DNA and RNA. Folate-dependent reactions also support methylation pathways. [1]

In Fmlave Brain Health, folate pairs with vitamin B12 to support methylation and nervous-system wellness as part of the formula’s B-vitamin foundation.

The Supplement Facts format uses mcg DFE for folate. When folic acid is present, the folic acid amount may be shown in parentheses. This formula lists Folate as 667 mcg DFE (400 mcg folic acid). [2]

References:
[1] National Institutes of Health, Office of Dietary Supplements. Folate — Health Professional Fact Sheet.
[2] U.S. Food and Drug Administration. Folate and Folic Acid on the Nutrition and Supplement Facts Labels.

Vitamin B12

Vitamin B12 is an essential B vitamin required for normal nervous-system function, healthy red blood cell formation, and DNA synthesis. It also functions as a cofactor for enzymes involved in methylation and cellular metabolism. [1]

In Fmlave Brain Health, vitamin B12 helps support the neurological foundation of a healthy aging cognitive routine. It works with folate to support methylation and normal nervous-system health.

This formula provides vitamin B12 as part of a broader daily cognitive support formula built around direct NAD+, Alpha-GPC, vitamin B12, and folate.

References:
[1] National Institutes of Health, Office of Dietary Supplements. Vitamin B12 — Health Professional Fact Sheet.