The Clinical Ledger // 5-Min Read

NAD Supplements Support Immunity, Skin Health & Vitality

NAD supplements support immunity, skin health, and day-to-day vitality. The core idea is to replenish cellular NAD⁺ (through nicotinamide riboside, NR), while vitamin D and polyphenols help relieve chronic inflammation and oxidative stress. Aging is associated with falling NAD⁺ levels and with immune/vascular dysfunction. Human trials show that NR can raise NAD⁺ and improve indicators like arterial stiffness and walking performance. Vitamin D and flavonoids such as quercetin can also regulate immune and inflammatory pathways. This is the result of pushing several interconnected systems forward at the same time.

By John | View Credentials →

Short answer: NAD supplements support immunity, skin health, and day-to-day vitality. The core idea is to replenish cellular NAD⁺ (through nicotinamide riboside, NR), while vitamin D and polyphenols help relieve chronic inflammation and oxidative stress. Aging is associated with falling NAD⁺ levels and with immune/vascular dysfunction. Human trials show that NR can raise NAD⁺ and improve indicators like arterial stiffness and walking performance. Vitamin D and flavonoids such as quercetin can also regulate immune and inflammatory pathways. This is the result of pushing several interconnected systems forward at the same time.

I’ve been taking Fmlave’s products myself. Based on my trust in them and the fact that their products come with complete COA lab reports—which convinces me the ingredients are dosed adequately and safely—I had my parents take their NAD+ capsules as well. Both of my parents are 71 years old. They have been taking them for about half a year now. The dark spots on my father’s face have clearly decreased. My mother used to need to rest for several minutes just to climb up to the third floor, but now she can go hiking with me on weekends and reach mountain tops over 300 meters in elevation. The effect has truly far exceeded my expectations. So I really wanted to know whether this is the effect of NAD+ itself, or the effect of the NAD+ blend. For that reason, I searched through a large amount of material online. Many articles say NAD can extend lifespan and help repair mitochondrial fragmentation. Many other articles say NAD supplements can support immunity, skin health, and daily vitality. Quite a few of them are from SCI journals. But most papers don’t integrate the evidence into a clear overall analysis, and they often feel very dense and hard to understand. Since I’m also trained in biology, I want to share what I found—and some of my own analysis—in plain language. The conclusion is that a well-designed NAD⁺ blend really can produce a 1 + 1 > 2 effect.

First, here is what various SCI journals say about NAD⁺ and the other ingredients:

Why does NAD⁺ matter for immune cells?
When immune cells activate, they rapidly consume large amounts of energy and NAD⁺. NAD⁺-dependent enzymes (sirtuins, PARPs, CD38) help these cells regulate gene expression, DNA repair, and cytokine production. Reference: https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-023-01031-5
Polyphenol redox / microvascular cluster: quercetin, grape seed, green tea, turmeric, resveratrol, acai, rose hips — antioxidant and anti-inflammatory actions.
Shilajit and fisetin — support mitochondrial function and stress resilience. Reference: https://pmc.ncbi.nlm.nih.gov/articles/PMC6364418/
Vitamin D₃ is like the master coordinator of the immune system: it coordinates innate and adaptive immunity.
Black pepper extract (piperine) — slows down how fast the body breaks ingredients down, making polyphenols easier to absorb.

What’s the relationship between NAD⁺ and the skin barrier?

Dermatology has accumulated a lot of human data on nicotinamide. Oral nicotinamide can reduce new actinic keratoses; topical nicotinamide improves hydration and barrier function. These effects rely on NAD⁺-related DNA repair. Reference: https://pubmed.ncbi.nlm.nih.gov/26488693/

What do grape seed, green tea, and other antioxidants do?

Oral antioxidant blends containing grape-seed proanthocyanidins have improved skin elasticity and hydration by reducing oxidative damage and MMP activity.

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Skin layer components
• Grape seed — microcirculation support and collagen protection.
• Rose hips — vitamin C for collagen synthesis and antioxidant defense.
• Green tea, turmeric, acai, resveratrol — Targeting UV-induced ROS.

Where does the “vitality” and energy support come from?

NAD⁺ and muscle function

Human studies show NAD⁺ declines noticeably with age in skeletal muscle. A 2024 clinical trial reported that six months of NR supplementation increased 6-minute walk distance versus placebo. Reference: https://pubmed.ncbi.nlm.nih.gov/38871717/